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Propofol dose. (Kieran Donnelly, 30 November 2015)

Could the dose of propofol used here not have significantly contributed to the higher mortality seen in the propfol group? The standard infusion for sedation upon the ITU - as found in the BNF - is 0.3–4 mg/kg/hour. This study used significantly greater infusion rates -  7-20 mg/kh/hour. Whilst creatine kinase levels remained similar, we must consider that propofol infusion syndrome can occur after 48 hours at a rate of 4 mg/kg/hour. Do investigators know if (and how?) propofol infusion syndrome would present after 24 hours of propofol infusion at 20mg/kg/hour in a rat? Whilst initially interesting, the infusion rates used here rather undercut any conclusions that can be drawn. read full comment

Comment on: Schläpfer et al. Critical Care, 19:45

Minute ventilation unit correction. (Todd Kelman, 11 September 2015)

In Table 2, units for minute ventilation are listed as ml/min, but are given in L/min (10.3 and 13.1 for mandatory and spontaneous mode of ventilation, respectively).  For comparison, units for minute ventilation in Table 5 are correct. read full comment

Comment on: Sinha et al. Critical Care, 17:R34

Corrected corresponding author email address (Matthew Rowan, 31 July 2015) read full comment

Comment on: Rowan et al. Critical Care, 19:243

Passive Leg Raising (PLR): « primum non nocere » (alexandre eghiaian, 13 July 2015)

Many thanks to the authors for this welcomed reminder about a not so easy to perform method, the PLR (1). However, in our opinion, going further on how to help realizing it is necessary to achieve its safe and efficient... read full comment

Comment on: Monnet et al. Critical Care, 19:18

Carbon dioxide overload: the neglected caveat of renal replacement therapy. (Marco Marano, 03 June 2015)

If  renal replacement therapy are offered as support to AKI as well as to multiple organ failure, I am quite surprised to find no notice of dialysis bath, because it could be a source of  carbon dioxide (CO2), not a negligible issue [1].... read full comment

Comment on: Ronco et al. Critical Care, 19:146

Simplified diagnostic tests in the ICU (Nicola Latronico, 05 May 2015)

Simplified diagnostic tests in the... read full comment

Comment on: Parry et al. Critical Care, 19:52

Limitations of observational studies in the prevention of cardiac-surgery AKI by sodium bicarbonate (Helmut Schiffl, 05 May 2015)

The secondary data reported by Dr Wetz and her colleagues suggest that perioperative sodium bicarbonate (SBIC) infusion may reduce the incidence of post-cardiac surgery (CS) - AKI in low risk patients [1]. This observational study is in contradiction with two recent meta-analyses demonstrating uniformly that SBIC does not reduce the incidence of CS-AKI but – on the contrary - harms these patients [2... read full comment

Comment on: Wetz et al. Critical Care, 19:183

Incorporation of the Shock Index (SI) into the Trauma-Induced Coagulopathy Clinical Score (TICCS): an interesting combination to be further investigated. (Martin TONGLET, 28 April 2015)

We would like to thank Pasquier and colleagues for their interest in our research on prehospital identification of trauma patients in need for Damage Control Resuscitation (DCR) and for their interesting suggestion. Whatever score or test is being used, we definitively and strongly believe that an early identification is pivotal for this dramatic situation. In this purpose, the Shock Index (SI) has, indeed, proven to be an interesting tool (1). Using an easy-to-calculate cut-off of SI >1, prehospital  SI calculation may facilitate the prehospital identification of normotensive patients at relatively high risk for Massive Transfusion (MT) and DCR. Mutschler and colleagues also demonstrated that SI calculation could help to identify patients in need for MT (2). In their application of... read full comment

Comment on: Pasquier et al. Critical Care, 19:152

Assumptions and Facts in the discussion of Brain Death (Noam Stadlan, 27 February 2015)

This comment reflects a number of commonly mentioned assumptions that are not necessarily true. The authors state that "on histopathological examination, about 60% of heart-beating donors have normal or minimal ischemic injury to the brainstem", quoting the seminal study by Wijdicks et al. However, they fail to mention the accompanying editorial comment(1) which states "The assessment method used by the authors(neuronal eosinophilia) is a fairly late development in the course of neuronal necrosis. More advanced techniques (DNA fragmentation, immunohistochemistry,in situ hybridization methods to explore caspase-mediated/independent mechanisms of cell death) could provide earlier indications of irreversible neuronal damage." In other words, not-dead by H and E staining criteria at 36 hours... read full comment

Comment on: Rady et al. Critical Care, 17:469

Calculation of "calculated ion gap" (Stella Glasmacher, 09 February 2015)

Dear Dr Leitch, I read your poster presentation with interest and would like to know which formula was used to calculate the "calculated ion gap" and whether the anion gap was also measured? Many thanks Stella read full comment

Comment on: Leitch et al. Critical Care, 11:P451

Quantification of urinary TIMP-2 and IGFBP-7 in cardiac surgery – Applying standards for reporting prognostic accuracy (Azra Bihorac, 23 January 2015)

We read with interest the results of the study by Wetz at el. examining the predictive performance of a novel urinary biomarker test (tissue-inhibitor of metalloproteinase 2 multiplied with urine insulin like growth factor binding protein 7, NephroCheckR) for the diagnosis of acute kidney injury (AKI) after cardiac surgery [1]. This test is the first FDA approved biomarker for risk stratification for AKI in critically ill patients, validated in two large multicenter trials [2-4]. In this study the definition and timing of outcomes, sample size and the reporting of statistical uncertainty all fall below standards in reporting and extrapolating the results of prognostic tests for clinical use [5, 6]. Measuring the occurrence of any stage of AKI up to sixty hours after surgery, as opposed to... read full comment

Comment on: Wetz et al. Critical Care, 19:3

Clinical utilization of TIMP-2 and IGFBP7 for detection of AKI following cardiac surgery (Eric Hoste, 16 January 2015)

We read with great interest the study by Wetz et al on the use of the biomarkers tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin growth factor-binding protein-7 (IGFBP7) for prediction of AKI after cardiac surgery [1]. The authors found that measurement of these biomarkers during the first day after surgery could identify patients at risk for AKI, while measurement 4 h after cardiopulmonary bypass (CPB) surgery or at the end of the procedure could not identify patients at risk for... read full comment

Comment on: Wetz et al. Critical Care, 19:3

Statement in the Methods section to be corrected (Martin Dunser, 09 January 2015)

An important point was brought to the attention of the authors following publication of this manuscript. The point referred to the statement in the Methods section that the electronic patient data management system described uses median filtering to eliminate artefacts from the raw signal. While this was the information of the authors until now, reconfirmation with the company revealed that this was not the case and that the system collects raw signals at one minute intervals. Therefore, the respective statement in the Methods section should correctly read based on this new information: "[...]. Hemodynamic and other vital parameters are collected at one minute intervals. [...]." read full comment

Comment on: Brunauer et al. Critical Care, 18:719

Methodology of echocardiographic measurements. (Lukasz R Nowak, 24 November 2014)

The results obtained by the authors are very promising and a possibility of employing such a small fluid volume for testing the fluid responsiveness is very attractive. Nonetheless I have some doubts about the methodology of echocardiographic measurements employed by the authors. The doubts arose for the first time when I looked at the Figure 1. of the article. It's title: "Photo of an echocardiographic Doppler flow velocity measurement from the level of the aortic annulus from the parasternal long-axis window" immediately raises concerns - it is not possible to measure aortic flow from the parasternal long axis (PLAX) window due to the beam non-alignement with flow direction (such measurements are performed from the apical window as the authors stated elsewhere in the article).... read full comment

Comment on: Wu et al. Critical Care, 18:R108

Amendment acknowledgement (Barbara Bottazzi, 19 November 2014)

The support of EU to AM (FP7-HEALTH-2011- project ADITEC - N°280873) is greatfully acknowledged. read full comment

Comment on: Mauri et al. Critical Care, 18:562

Testing the hypothesis that glucose administration plus tight glucose control is beneficial has the potential to harm (Simon Finfer, 04 November 2014)

In their article Mazeraud and colleagues attempt to explain why tight glucose control was benefiical in the first Leuven trial and not in other trials. They conclude that an interventional study evaluating liberal and restrictive glucose intake during IIT is warranted to provide reliable evidence. While such a trial would provide evidence about the modifying effect of glucose administration on the effects of IIT, it would not provide any information to decide whether IIT was beneficial in the first place. As they note, the EPaNIC study compared two feeding strategies in patients treated with IIT and did not support the further use of the feeding strategy employed in the first Leuven trial. The trial which would be most interesting would be one in which the two feeding... read full comment

Comment on: Mazeraud et al. Critical Care, 18:232

Authors' comment: Correction to Table One  (Ceri Battle, 03 November 2014)

Column 5 of the data in Table One gives the numbers of patients in the validation sample with no complications. It currently reads 161 and it should read 134. The percentage given (57%) is correct. read full comment

Comment on: Battle et al. Critical Care, 18:R98

Wrong typo in the abstract of the original article leads to a wrong argument in another (Hsiu-Nien Shen, 05 November 2013)

Dear... read full comment

Comment on: et al. Critical Care, 16:R33

Reason for concern (Christian Wiedermann, 03 September 2013)

We had previously noticed the renal replacement therapy (RRT) data listed under "Hemofiltration" in Table 3 of the Critical Care (CC) publication by Boussekey et al. However, only 8 total patients required RRT according to that table compared with a total 82 of patients requiring RRT in the study's entire... read full comment

Comment on: Wiedermann et al. Critical Care, 17:444

Fascinating study which may have more stories to tell (, 27 June 2013)

Congratulations to the authors on this fascinating study. We have been waiting a long time for someone to attempt true GFR measurements on AKI patients, not an easy task.... read full comment

Comment on: Bragadottir et al. Critical Care, 17:R108

Paracelsus' wisdom (Giuseppe Citerio, 22 May 2013)

I¿ve read with interest this paper by Schiefecke and others on parenteral Diclofenac infusion in SAH patients..... read full comment

Comment on: Schiefecker et al. Critical Care, 17:R88

BD increase is not always due to shock (Venkatesh Srinivasa, 24 April 2013)

BD value is, when it reflects lactic acidosis. BD can increase during hyperchloremia (hypertonic resuscitation, NS resuscitation) where it is not an indicator of shock. Nonetheless, increased BD from any reason has been shown to have worse outcome. This study emphasizes the need for RCT's. read full comment

Comment on: Mutschler et al. Critical Care, 17:R42

Toothbrushing for preventing ventilator-associated pneumonia: a live issue worth further investigation (Wan-Jie Gu, 07 March 2013)

Reply: We would like to thank Labeau and Blot for their letter and insightful comments.[1] For Critical ill patients with intubation, dental plaque and the oral mucosa can be colonized with potential pathogens associated with ventilator-associated pneumonia (VAP).[2] Observational studies demonstrated that oral care with toothbrushing improved oral hygiene and reduced plaque load.[3,4] Theoretically, toothbrushing may have favorable effect on the development of VAP. However, evidence on this topic still remains limited, which precludes final verdicts and strong clinical recommendations. Moreover, diagnosis is crucial for the prevention of VAP, but debate remains as to the optimal means of diagnosing VAP. In this case, further research on toothbrushing for VAP prevention is warranted. We... read full comment

Comment on: Labeau et al. Critical Care, 17:417

Sad loss -- I will always remember Professor Traber's resonant voice! (Philip M Kober, JD, MD, PhD, 17 December 2012)

I am very saddened to hear of Dr. Dan Traber's death. I am honored to have known him since my days in graduate school in physiology at Loyola University of Chicago. I will always remember his resonant voice -- "Traber, Galveston" -- at American Physiological Society, FASEB, and Shock Society meetings. He will be missed!

Philip M. Kober, JD, MD, PhD read full comment

Comment on: Prough et al. Critical Care, 16:169

Restful organs (Michael Rodgers, 08 November 2012)

Chawla et al make a case for "resting" the kidney. I find this a rather peculiar, non-medical term to use. I presume what they mean is to reduce the metabolism of the... read full comment

Comment on: Chawla et al. Critical Care, 16:317